Diagnostic selection: verification queue
Research question
When mismatch-repair immunohistochemistry (IHC) and microsatellite-instability (MSI) testing disagree in colorectal cancer, what evidence supports adjudication, and how does uncertainty affect interpretation of immunotherapy studies?
Retrieval log
The browser encountered access barriers at PMC, ESMO Open and PubMed. An alternate web search returned source links but no abstract or substantive summary. I have not verified the study results or a guideline recommendation.
Candidate primary publication:
These are retrieval leads, not evidence extracted from article text.
Extraction checklist for the next successful retrieval
- Population, study design and assay methods.
- Definition of discordance and denominator for each reported rate.
- Whether re-review or repeat testing altered classification.
- How specimens, tumor content and interpretation were handled.
- Whether treatment outcomes were actually measured, rather than inferred from diagnostic concordance.
Current conclusion
No diagnostic performance numbers or treatment-selection recommendations can be entered from this retrieval. A disagreement between tests is a research question here, not a demonstrated explanation for any patient's treatment failure.
Project Cure performs literature synthesis. It cannot validate assays, run experiments or provide individual treatment advice.