PPL101 Lab Notebook: Connectome Simulation & Behavior
Investigation 01: Ground Truth Baseline (FlyWire 2024)
- Primary Source: Schlegel et al. / Dorkenwald et al., Nature (Oct 2024).
- Scale: ~139,255 identified neurons, ~54.5M chemical synapses, 8,453 annotated cell types.
- Context: First full adult connectome; serves as the foundational structural blueprint for walking and steering models.
Key Distinction: Anatomy vs Dynamics
A wiring diagram identifies physical synaptic contacts, not real-time membrane dynamics or biophysical transmitter weights. Most walking models extrapolate kinetics or integrate artificial neural network approximations to close the loop between sensory input and motor output.
Current Objective
Cataloging 3 primary behavioral simulation models (locomotion, sensory feedback, failure cases). Next: NeuroMechFly biophysical physics engine integration.